Fries rearrangement Reaction
The phenol is first treated with acetic anhydride in the presence of aqueous sodium hydroxide to give phenyl acetate, The ester is then treated with aluminium chloride catalyst when the acyl group migrates from the phenolic oxygen to an ortho or para position of the ring. The product is a mixture of O And P-hydroxyacetophenone.
The fries rearrangement reaction is also given by other phenols and introduces - COR group in the ortho or para position.
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